Solve Your Health Issues with a Ketogenic Diet
| Ketogenic Diet Plan: Get Started Here! Here's how to start a ketogenic diet plan, what to expect, whether it's dangerous and the great benefits. |
Showing posts with label carb - pro low carb. Show all posts
Showing posts with label carb - pro low carb. Show all posts
10.7.11
Ketogenic Diet Resource - Website
Solve Your Health Issues with a Ketogenic Diet
Low Carb Research - Nutrition & Metabolism Society
Low Carb Research
The past few decades have been enlightening in terms of scientific knowledge about low carb diets. The research which highlights the safety, indeed the necessity in some cases, and the efficacy of carbohydrate restriction can no longer be denied or ignored. Section Links: 2011 | 2010 | 2009 | 2008 | 2007| 2006 | 2005
2011
- A Low Carbohydrate, High Protein Diet Slows Tumor Growth and Prevents Cancer Initiation. Victor W. Ho, Kelvin Leung, Anderson Hsu, Beryl Luk, June Lai, Sung Yuan Shen, Andrew I. Minchinton, Dawn Waterhouse, Marcel B. Bally, Wendy Lin, Brad H. Nelson, Laura M. Sly, and Gerald Krystal
- A ketogenic diet suppresses seizures in mice through adenosine A1 receptors. Susan A. Masino, Tianfu Li, Panos Theofilas, Ursula S. Sandau, David N. Ruskin, Bertil B. Fredholm, Jonathan D. Geiger, Eleonora Aronica and Detlev Boison2
- Metabolic management of brain cancer. Thomas N. Seyfried, Michael A. Kiebish, Jeremy Marsh, Laura M. Shelton, Leanne C. Huysentruyt, and Purna Mukherjee
- Low-Carbohydrate Diet Review : Shifting the Paradigm. Adele H. Hite, MAT; Valerie Goldstein Berkowitz, MS, RD, CDE and Keith Berkowitz, MD, MBA
1.7.11
Dietary Guidelines Advisory Committee - Should Be Held Accountable | Carbohydrates Can Kill
The Dietary Guidelines Advisory Committee Should Be Held Accountable | Carbohydrates Can Kill
By taking a quick glance, the proposed Dietary Guidelines for Americans, 2010 [1] are nothing new but a worse copy of their predecessors. Aside the possible conspiracy that involves politics and favoritism, the guidelines reflect the irresponsibility and naivety of their authors, the Dietary Guidelines Advisory Committee.
Based on the decades old concepts that carbohydrates are a darling and fats are an evil, the current and older versions of Dietary Guidelines have helped both the US and global populations become heavier [2] and increasingly suffer from diseases such as diabetes mellitus, coronary artery disease, arthritis, Alzheimer’s disease, and cancers. [3, 4] At the same time, as a result, the health care cost has steeply risen with no hope of reversal in any time soon. [5] Having known all the facts, the Advisory Committee has committed gross negligence by continuing to recommend a worse version of the old dietary guidelines even with a reduced fat consumption. The act of the Advisory Committee is irresponsible.
By taking a quick glance, the proposed Dietary Guidelines for Americans, 2010 [1] are nothing new but a worse copy of their predecessors. Aside the possible conspiracy that involves politics and favoritism, the guidelines reflect the irresponsibility and naivety of their authors, the Dietary Guidelines Advisory Committee.
Based on the decades old concepts that carbohydrates are a darling and fats are an evil, the current and older versions of Dietary Guidelines have helped both the US and global populations become heavier [2] and increasingly suffer from diseases such as diabetes mellitus, coronary artery disease, arthritis, Alzheimer’s disease, and cancers. [3, 4] At the same time, as a result, the health care cost has steeply risen with no hope of reversal in any time soon. [5] Having known all the facts, the Advisory Committee has committed gross negligence by continuing to recommend a worse version of the old dietary guidelines even with a reduced fat consumption. The act of the Advisory Committee is irresponsible.
Dietary Guidelines 2010 - Must Do No Harm Or Be Overhauled. | Carbohydrates Can Kill
The Dietary Guidelines 2010 Must Do No Harm Or Be Overhauled. | Carbohydrates Can Kill
The report of Dietary Guidelines Advisory Committee on the Dietary Guidelines for Americans, 2010, has stirred up a national controversy and is facing a wave of fierce objections from the public and many health and nutritional experts outside the US Government and the special interest groups.
The controversy is centered on the soundness of these guidelines, which are mostly a copy of the earlier guidelines since 1980, with emphasis on the more consumption of daily calories from carbohydrates and the less from fats especially the saturated fats. [1]
The reliability of these guidelines are further questioned when both the statistics and the layman’s observation concur that the US population has been rapidly growing heavier to that at least six or seven out of every ten adults are either overweight or obese since 1980. [2] Worst of all, the trends in overweight and obesity have also moved into the younger population including toddlers and infants. [3, 4]
Despite that the previous Dietary Guidelines and Food Pyramids have been well publicized, reports such as this, by JD Wright, et al. “Trends in Intake of Energy and Macronutrients—United States, 1971-2000”, points out that, during the study period, the prevalence of obesity in the US increased from 14.5% to 30.9%, the average daily calorie intake increased from 2,450 kcals to 2,618 kcals for men and from 1,543 kcals to 1,877 kcals for women; the percentage of kcals from carbohydrate increased from 42.4% to 49.0% for men and from 45.4% to 52.6% for women; while the percentage of kcals from total fat “ironically decreased’ from 36.9 to 32.8% for men and from 36.1% to 32.8% for women; and the percentage of kcals from saturated fat also “notably decreased” from 13.5% to 10.9% for men and 13.0% to 11.0% for women.
Only a slight decrease from protein was observed. A USDA food consumption survey for the periods between 1989 and 1991, and between 1994 and 1996, indicates the increase of daily calorie intake was caused by higher carbohydrate consumption. The NHANES data for 1971-2000 concur the USDA data, and point out that an increase of 62.4 grams in carbohydrates for women and 67.77 grams for men, while an increase of 6.5 grams in fat for women and a decrease of 5.3 grams for men. Based on these official data, excess consumption in carbohydrate, not in fat, is responsible for the uptrend in obesity for the decades since 1980. [5]
The report of Dietary Guidelines Advisory Committee on the Dietary Guidelines for Americans, 2010, has stirred up a national controversy and is facing a wave of fierce objections from the public and many health and nutritional experts outside the US Government and the special interest groups.
The controversy is centered on the soundness of these guidelines, which are mostly a copy of the earlier guidelines since 1980, with emphasis on the more consumption of daily calories from carbohydrates and the less from fats especially the saturated fats. [1]
The reliability of these guidelines are further questioned when both the statistics and the layman’s observation concur that the US population has been rapidly growing heavier to that at least six or seven out of every ten adults are either overweight or obese since 1980. [2] Worst of all, the trends in overweight and obesity have also moved into the younger population including toddlers and infants. [3, 4]
Despite that the previous Dietary Guidelines and Food Pyramids have been well publicized, reports such as this, by JD Wright, et al. “Trends in Intake of Energy and Macronutrients—United States, 1971-2000”, points out that, during the study period, the prevalence of obesity in the US increased from 14.5% to 30.9%, the average daily calorie intake increased from 2,450 kcals to 2,618 kcals for men and from 1,543 kcals to 1,877 kcals for women; the percentage of kcals from carbohydrate increased from 42.4% to 49.0% for men and from 45.4% to 52.6% for women; while the percentage of kcals from total fat “ironically decreased’ from 36.9 to 32.8% for men and from 36.1% to 32.8% for women; and the percentage of kcals from saturated fat also “notably decreased” from 13.5% to 10.9% for men and 13.0% to 11.0% for women.
Only a slight decrease from protein was observed. A USDA food consumption survey for the periods between 1989 and 1991, and between 1994 and 1996, indicates the increase of daily calorie intake was caused by higher carbohydrate consumption. The NHANES data for 1971-2000 concur the USDA data, and point out that an increase of 62.4 grams in carbohydrates for women and 67.77 grams for men, while an increase of 6.5 grams in fat for women and a decrease of 5.3 grams for men. Based on these official data, excess consumption in carbohydrate, not in fat, is responsible for the uptrend in obesity for the decades since 1980. [5]
William Banting - low carb in 1863
About William Banting, author of Letter on Corpulence, UK
But in reality, they are not. The first low-carbohydrate diet book was written in 1863 by William Banting as a service to his fellow Man. His name passed into the language as the verb 'to bant'.
That the 'Banting diet' works has been attested to by 140 years of epidemiological studies and clinical trials.
For the sake of our health, it is time we started 'banting' again.
Summary
For two decades 'healthy eating' propaganda has influenced the way we eat. Over the same period there has been a consequent dramatic rise in obesity and associated conditions. This has led to a backlash which has seen a rash of diet books advocating high-fat, low-carbohydrate diets described as 'new' and 'revolutionary'.But in reality, they are not. The first low-carbohydrate diet book was written in 1863 by William Banting as a service to his fellow Man. His name passed into the language as the verb 'to bant'.
That the 'Banting diet' works has been attested to by 140 years of epidemiological studies and clinical trials.
For the sake of our health, it is time we started 'banting' again.
Barry Groves Phd - "Eat fat Get thin"
Uploaded by naturalfoodfinder on Sep 28, 2010
Barry Groves Phd - interview 'What is Needed For Low-Carb Diet Recognition'
Interview here - Moved to LivinLaVidaLowCarb.com/Blog: Groves: 'Population-Led Revolt' Needed For Low-Carb Diet Recognition
Dr. Barry Groves personally grew to appreciate the role of dietary fat
Barry Groves Pdh - website
Extract - From Jimmy Moore, LivinLaVidaLowCarb show:
There are so many truly remarkable and fascinating people who work behind-the-scenes to share what they have personally learned and studied about livin' la vida low-carb. I've been privileged enough to interview quite a few of these people over the past couple of years and I have another incredible interview to share with you today.
Several of you e-mailed me to request I e-mail Dr. Barry Groves from Great Britain about the work he is doing on behalf of the low-carb lifestyle. The more I started reading http://www.second-opinions.co.uk, I couldn't believe I hadn't heard of him before! Well, let's just say I know who he is now and I'm honored to have had the opportunity to ask him a few questions about livin' la vida low-carb.
Dr. Barry Groves personally grew to appreciate the role of dietary fat
Barry Groves Pdh - website
Extract - From Jimmy Moore, LivinLaVidaLowCarb show:
There are so many truly remarkable and fascinating people who work behind-the-scenes to share what they have personally learned and studied about livin' la vida low-carb. I've been privileged enough to interview quite a few of these people over the past couple of years and I have another incredible interview to share with you today.
Several of you e-mailed me to request I e-mail Dr. Barry Groves from Great Britain about the work he is doing on behalf of the low-carb lifestyle. The more I started reading http://www.second-opinions.co.uk, I couldn't believe I hadn't heard of him before! Well, let's just say I know who he is now and I'm honored to have had the opportunity to ask him a few questions about livin' la vida low-carb.
Low Carb - Arctic adventures in Diet (1935)
Low Carbohydrate Nutrition: Adventures in Diet (Part 1) By Vilhjalmur Stefansson
Low Carbohydrate Nutrition: Adventures in Diet (Part 2) By Vilhjalmur Stefansson
Low Carbohydrate Nutrition: Adventures in Diet (Part 3) By Vilhjalmur Stefansson
intro:
By Vilhjalmur Stefansson
In 1906 I went to the Arctic with the food tastes and beliefs of the average American. By 1918, after eleven years as an Eskimo among Eskimos, I had learned things which caused me to shed most of those beliefs. Ten years later I began to realize that what I had learned was going to influence materially the sciences of medicine and dietetics. However, what finally impressed the scientists and converted many during the last two or three years, was a series of confirmatory experiments upon myself and a colleague performed at Bellevue Hospital, New York City, under the supervision of a committee representing several universities and other organizations.
Not so long ago the following dietetic beliefs were common: To be healthy you need a varied diet, composed of elements from both the animal and vegetable kingdoms. You got tired of and eventually felt a revulsion against things if you had to eat them often. This latter belief was supported by stories of people who through force of circumstances had been compelled, for instance, to live for two weeks on sardines and crackers and who, according to the stories, had sworn that so long as they lived they never would touch sardines again. The Southerners had it that nobody can eat a quail a day for thirty days.
There were subsidiary dietetic views. It was desirable to eat fruits and vegetables, including nuts and coarse grains. The less meat you ate the better for you. If you ate a good deal of it, you would develop rheumatism, hardening of the arteries, and high blood pressure, with a tendency to breakdown of the kidneys - in short, premature old age. An extreme variant had it that you would live more healthy, happily, and longer if you became a vegetarian.
Low Carbohydrate Nutrition: Adventures in Diet (Part 2) By Vilhjalmur Stefansson
Low Carbohydrate Nutrition: Adventures in Diet (Part 3) By Vilhjalmur Stefansson
intro:
Adventures in Diet (Part 1)
Harper's Monthly Magazine, November 1935By Vilhjalmur Stefansson
In 1906 I went to the Arctic with the food tastes and beliefs of the average American. By 1918, after eleven years as an Eskimo among Eskimos, I had learned things which caused me to shed most of those beliefs. Ten years later I began to realize that what I had learned was going to influence materially the sciences of medicine and dietetics. However, what finally impressed the scientists and converted many during the last two or three years, was a series of confirmatory experiments upon myself and a colleague performed at Bellevue Hospital, New York City, under the supervision of a committee representing several universities and other organizations.
Not so long ago the following dietetic beliefs were common: To be healthy you need a varied diet, composed of elements from both the animal and vegetable kingdoms. You got tired of and eventually felt a revulsion against things if you had to eat them often. This latter belief was supported by stories of people who through force of circumstances had been compelled, for instance, to live for two weeks on sardines and crackers and who, according to the stories, had sworn that so long as they lived they never would touch sardines again. The Southerners had it that nobody can eat a quail a day for thirty days.
There were subsidiary dietetic views. It was desirable to eat fruits and vegetables, including nuts and coarse grains. The less meat you ate the better for you. If you ate a good deal of it, you would develop rheumatism, hardening of the arteries, and high blood pressure, with a tendency to breakdown of the kidneys - in short, premature old age. An extreme variant had it that you would live more healthy, happily, and longer if you became a vegetarian.
Fat and Carbs Library - research papers & articles
Diet & Cancer - Metabolism Society
| Many aggressive cancers depend on anaerobic glycolysis for ATP production, as has been known since first described by Otto Warburg in the 1920’s. The remarkable success of modern PET scanning in the detection, staging and prognosis of many cancers using F-18 Fluorodeoxyglucose (FDG) reflects this dependence. Very low carbohydrate ketogenic (VLCK) diets have inhibited cancer growth in animal studies and in a human case study. Ketone bodies in culture media have inhibited cancer growth in cell culture studies [1], [5], [6]. While the mechanism of cancer inhibition is unlikely to be simple glucose deprivation, several plausible mechanisms have been proposed. VLCK diets cause tonic reductions in hormones that are supportive of tumor growth including insulin, IGF7, IL6 and other inflammatory cytokines. Other metabolic effects include apoptosis due to increased plasma fatty acids, and inhibition of fatty acid synthase, a target of chemotherapeutic agents. While we actively explore cellular and metabolic effects of ketone bodies themselves in our own laboratories, we are also recruiting patients in a nutritional Clinical Trial of carbohydrate restriction in collaboration between the Albert Einstein College of Medicine and Downstate Medical Center. The two principle aims are to: 1) Determine safety and feasibility of a 28 day VLCK diet in 12 subjects with FDG avid cancers. 2) Monitor change in PET FDG uptake between the beginning and end of the trial as a surrogate marker for efficacy (as has been done in lymphoma, lung cancer, breast cancer and other malignancies). Five patients with metastatic cancer have completed four weeks of a VLCK diet without adverse effects. We are looking to recruit another 7 patients. Please take a look at our website for more information. |
30.6.11
More fat less carb is best - recent Studies
That Paleo Guy: Low Carbohydrate Diet Review: Shifting the Paradigm
Extract:
Extract:
"For those of us who have been on board with, and operating under this paradigm for some time now, there is really nothing new at all in this review. However, it does provide a good summary of all of the common issues and concerns around low-carbing, particular those that are often put forward by clinician's themselves. There is the nod, in this review, to the fact that these clinicians are clinging to a wisdom and practise that is protective of their own beliefs and biases rather than focused on the patient. As suggest by the authors, you can advocate all the low glycaemic index breads you like as a way to manage diabetes, for example, but the glucometer doesn't lie.
Is this a game changer? Doubt it. As I mentioned in my introduction, I have had health professionals tell me that they would only consider a change in clinical approach if I could provide a solid meta-analysis or Cochrane review (obviously thinking I couldn't). When such evidence is produced, it still isn't enough and other reasons as to why 'the science' is wrong come to the fore (clinical best practise seems to be a matter of faith rather than physiology and commonsense). However, there will be those clinicians who have perhaps been sitting on the fence with this paradigm and who just haven't had the time to do an in-depth review around all the common issues. This paper is for them, and may just be enough to knock them off the fence and onto the low carb side. More importantly, this paper, with its ease of reading, is for the patient. There isn't a lot in here that would bog a patient down, and for clinicians wanting to take their patient down the low carb pathway (maybe by applying paleo principles), this could be the ideal review to pass on to their patient to give them confidence in that pathway.
This review isn't going to create a seismic shift in paradigm, but it is certainly building pressure and rumbling in the right direction."
Dietary Guidelines Committee Receives The Spanking It Deserves
Fat Head » The Dietary Guidelines Committee Receives The Spanking It Deserves
The journal Nutrition just published a paper titled In The Face Of Contradictory Evidence: Report Of The Dietary Guidelines For Americans Committee. The authors are Adele Hite, MAT; Richard Feinman, PhD; Gabriel Guzman, PhD; Morton Satin, MSc; Pamela Schoenfeld, RD; and Richard Wood, PhD.
Sure, a lot of bloggers ripped the 2010 Dietary Guidelines for spouting the same old nonsense, but we’re bloggers, not academic researchers, so we’re easy to ignore.
It’s not so easy to dismiss this group, especially when their paper is published in a respected journal. This paragraph from the abstract pretty much sums it up:
The journal Nutrition just published a paper titled In The Face Of Contradictory Evidence: Report Of The Dietary Guidelines For Americans Committee. The authors are Adele Hite, MAT; Richard Feinman, PhD; Gabriel Guzman, PhD; Morton Satin, MSc; Pamela Schoenfeld, RD; and Richard Wood, PhD.
Sure, a lot of bloggers ripped the 2010 Dietary Guidelines for spouting the same old nonsense, but we’re bloggers, not academic researchers, so we’re easy to ignore.
It’s not so easy to dismiss this group, especially when their paper is published in a respected journal. This paragraph from the abstract pretty much sums it up:
Although appealing to an evidence-based methodology, the DGAC Report demonstrates several critical weaknesses, including use of an incomplete body of relevant science; inaccurately representing, interpreting, or summarizing the literature; and drawing conclusions and/or making recommendations that do not reflect the limitations or controversies in the science.In fact, the topic headings in the paper read like a list of charges. Here are few sample headings:
Macronutrients: Research questions are formulated in a way that prevents a thorough investigation of the literature
Macronutrients and weight loss: Science is inaccurately summarized
Low-carbohydrate diets: Science is inaccurately represented
Low-carbohydrate diets: Conclusions do not reflect quantity and/or quality of relevant science
Effects of saturated fat: Answers based on an incomplete body of relevant science
Effects of saturated fat: Science is inaccurately represented or summarized
Diabetes and fat: Science is inaccurately represented or summarized
Dietary fiber and whole grains: Conclusions do not reflect the quantity and/or quality of science
Salt: Recommendations do not reflect limitations and uncertainties of the science
You get the idea. Within each topic, the authors point out the many flaws in the scientific “evidence” cited to support the 2010 Dietary Guidelines … the cherry-picking, the incorrect conclusions, and the contradictions. If you’re interested in the details, you can read the full paper.
27.6.11
Matt Stone - Dr Kurt Harris critiques
Archevore - Archevore Blog - 180 + 180 = 360
Reader Jeff writes in with a comment about Matt Stone of 180 Health.
Matt is the subtle attention-shy guy who poses shirtless holding a pig’s head on his blog.
Matt doesn’t really need any attention from me, he is busy commenting in a “contrarian” fashion all over the blogosphere right now. However, enough readers are asking me what I think that I should say something, I suppose.
His first target is really a straw man. PaNu, Wholehealthsource and Peter at Hyperlipid all target fructose and linoleic acid as the main causes of metabolic disturbance in the western diet. Even Gary Taubes in his recent lectures has said "it may indeed all be fructose". None of us, read carefully, claims that "carbohydrates = disease".
His observation that some people may not feel good, even "hypometabolic" on VLC I don't take issue with. It seems like common sense that you might feel better eating more or less of just about anything. As long as you are avoiding the neolithic agents, tinker away! (That's for Brett and Nassim)
My blog with 60 or so main posts and pushing 3000 comments does not have any content from me prescribing precise ratios of anything, except for when advising how to lose weight. I respect the Optimal diet and Peter but I think any tightly defined macro ratio is rather artificial, including Kwasniewski's. I am sure that bias shows in my irritation at the bodybuilding questions : )
At the same time, Stone's statement that long term ketogenic eating per se ruins your metabolism is much less supportable than the "all carbs are metabolic poison" straw man he is attacking. Again, even Taubes does not really say this in GCBC.
My own view on the ratio of carbs in the diet should be pretty clear by now.
1) I think a wide range is tolerable for those with normal metabolism. For those about to ask "how wide" - OK, let's say 5% to 40% or even more if you can tolerate it and the rest of your food is very high quality. If your metabolism is damaged (you know who you are - type II or obesity prone) or you don't tolerate starches well like me, you should probably stay on the low end of carb intake.
2) I think the paleolithic principle itself argues against LC and VLC being damaging the same way it argues against plants and all carbs as being poison. It just makes no sense, as it implies that humans in any given econiche, even one rich in a huge variety of animal foods, would have been at risk of metabolic damage from being in long term mild ketosis if they were not able to find enough starchy tubers and fruit in season. (We've agreed that grains like white rice are a recent food, I hope).
Enough nonstarchy greens to choke a gorilla with an otherwise all animal diet will not keep you totally out of ketosis, I guarantee. If it did, I wouldn't want to share your bathroom.
Of course, you can start eating a lot of coconuts like the Tokelauans or Kitavans and you can elevate your B-hydroxybutyrate even with a normal carb intake. Uh-oh - now our thyroid glands will die!
3) I suppose it is a corollary of my own paleo principle that I don't like approaches that require "seeking" behavior for something that provides only calories. "I'd better eat some carbs or my thyroid and adrenal glands will be screwed up". Really? HGs had to consciously think about whether they were getting enough starch? Or is starch just something that we eat because it helps us not starve?
4) On the other hand, avoidance behavior is totally compatible with the paleolithic principle. "Avoid that, as it is outside of our evolutionary experience or causes metabolic effects that are outside our experience in the amounts that are available". This is my template. Fructose, wheat and excess linoleic acid.
5) It is true that being in negative energy balance – losing weight -generates an energy conserving response. That is not surprising. Once you are at equilibrium though, does a lower free T3 with normal TSH and T4 on lower carbs mean something pathologic? What if you had cold hands and a low basal temperature when even you ate 50% of calories as carbs? Are you now supposed to go from 10% to 70% to "restart your thyroid" or are you rather still hypothyroid because you have always been hypothyroid and you are just no longer euphoric now that you have stopped losing weight? Remembering your mood or body sensations one hour ago is hard enough. We are supposed to remember what they were years ago?
6) In answer to the idea that we need to carefully regulate macronutrient ratios to control the function of our thyroid and adrenal glands I have only one comment for now:
Lacks biological and evolutionary plausibility.
To summarize, Matt is a clever and entertaining writer, but his main target is a straw man, as most of the science oriented paleonutrition blogs are not really "low carb" blogs at all. His observation that starch per se need not be unhealthy is not really that controversial.
Matt's claims about his own serum BG after meals should be published as a case report in a medical journal. They are at odds with clinical studies I have read on glucose metabolism in normal highly insulin sensitive young people (can you say "superhuman"?).
Matt's got some good observations, but is over or mis-interpreting the literature in the realm of endocrinology. I did not notice if he has any medical or scientific credentials, but his views of hormonal action lack nuance, to say the least. He is also avidly mining the "I feel like shite, it must be my thyroid or adrenal glands" meme.
180 + 180 = 360
Friday, February 5, 2010 at 1:31PM
Reader Jeff writes in with a comment about Matt Stone of 180 Health.
Matt is the subtle attention-shy guy who poses shirtless holding a pig’s head on his blog.
Matt doesn’t really need any attention from me, he is busy commenting in a “contrarian” fashion all over the blogosphere right now. However, enough readers are asking me what I think that I should say something, I suppose.
Jeff writes regarding Matt Stone's guest post on Tom Naughton's blog re colton osborn's question- i just went over and read the post at the link. i think the key section is:
Jeff here- most of what is in the post is fully compatible with PaNu. But Matt Stone asserts that once you've been on zero carb or very low carb for a while [several years] you'll run into problems as specified above. The carbs he recommends sound like potatoes and rice, not clear what he thinks about whole grains, but the bottom line question seems to be about thyroid function over the long term. I read the post and it starts out reasonably. Matt's hyping a pseudo -contrarian position that has some truth to it, but reading him later he goes off the rails when he starts talking about cortisol and thyroid function.And therein lies the true danger of uber-low-carbohydrate diets. All my experience tells me that, the first few years aside, a low-carbohydrate diet and certainly a full-blown ketogenic diet exacerbates a low metabolism. It is not a matter of having a genetically-doomed dysfunctional thyroid gland; it is fixable, and it lies at the core of the health problems we’ve seen explode over the last century. This is why all prolonged restricted diets, low-carb included, in the words of Robert Atkins himself (from page 303 of Dr. Atkins’ New Diet Revolution):“…tend to shut down thyroid function. This is usually not a problem with the thyroid gland but with the liver, which fails to convert T4 into the more active thyroid principle, T3. The diagnosis is made on clinical grounds with the presence of fatigue, sluggishness, dry skin, coarse or falling hair, an elevation in cholesterol, or a low body temperature.”To that I will add constipation, bad moods, heartburn, cold hands and feet, and a whole host of other minor but significant health problems. To get an idea of how “shutting down the thyroid” can manifest, Mark Starr’s chapter on Hypothyroidism symptoms is 83 pages long.
His first target is really a straw man. PaNu, Wholehealthsource and Peter at Hyperlipid all target fructose and linoleic acid as the main causes of metabolic disturbance in the western diet. Even Gary Taubes in his recent lectures has said "it may indeed all be fructose". None of us, read carefully, claims that "carbohydrates = disease".
His observation that some people may not feel good, even "hypometabolic" on VLC I don't take issue with. It seems like common sense that you might feel better eating more or less of just about anything. As long as you are avoiding the neolithic agents, tinker away! (That's for Brett and Nassim)
My blog with 60 or so main posts and pushing 3000 comments does not have any content from me prescribing precise ratios of anything, except for when advising how to lose weight. I respect the Optimal diet and Peter but I think any tightly defined macro ratio is rather artificial, including Kwasniewski's. I am sure that bias shows in my irritation at the bodybuilding questions : )
My own view on the ratio of carbs in the diet should be pretty clear by now.
1) I think a wide range is tolerable for those with normal metabolism. For those about to ask "how wide" - OK, let's say 5% to 40% or even more if you can tolerate it and the rest of your food is very high quality. If your metabolism is damaged (you know who you are - type II or obesity prone) or you don't tolerate starches well like me, you should probably stay on the low end of carb intake.
2) I think the paleolithic principle itself argues against LC and VLC being damaging the same way it argues against plants and all carbs as being poison. It just makes no sense, as it implies that humans in any given econiche, even one rich in a huge variety of animal foods, would have been at risk of metabolic damage from being in long term mild ketosis if they were not able to find enough starchy tubers and fruit in season. (We've agreed that grains like white rice are a recent food, I hope).
Enough nonstarchy greens to choke a gorilla with an otherwise all animal diet will not keep you totally out of ketosis, I guarantee. If it did, I wouldn't want to share your bathroom.
Of course, you can start eating a lot of coconuts like the Tokelauans or Kitavans and you can elevate your B-hydroxybutyrate even with a normal carb intake. Uh-oh - now our thyroid glands will die!
3) I suppose it is a corollary of my own paleo principle that I don't like approaches that require "seeking" behavior for something that provides only calories. "I'd better eat some carbs or my thyroid and adrenal glands will be screwed up". Really? HGs had to consciously think about whether they were getting enough starch? Or is starch just something that we eat because it helps us not starve?
4) On the other hand, avoidance behavior is totally compatible with the paleolithic principle. "Avoid that, as it is outside of our evolutionary experience or causes metabolic effects that are outside our experience in the amounts that are available". This is my template. Fructose, wheat and excess linoleic acid.
5) It is true that being in negative energy balance – losing weight -generates an energy conserving response. That is not surprising. Once you are at equilibrium though, does a lower free T3 with normal TSH and T4 on lower carbs mean something pathologic? What if you had cold hands and a low basal temperature when even you ate 50% of calories as carbs? Are you now supposed to go from 10% to 70% to "restart your thyroid" or are you rather still hypothyroid because you have always been hypothyroid and you are just no longer euphoric now that you have stopped losing weight? Remembering your mood or body sensations one hour ago is hard enough. We are supposed to remember what they were years ago?
6) In answer to the idea that we need to carefully regulate macronutrient ratios to control the function of our thyroid and adrenal glands I have only one comment for now:
Lacks biological and evolutionary plausibility.
To summarize, Matt is a clever and entertaining writer, but his main target is a straw man, as most of the science oriented paleonutrition blogs are not really "low carb" blogs at all. His observation that starch per se need not be unhealthy is not really that controversial.
Matt's claims about his own serum BG after meals should be published as a case report in a medical journal. They are at odds with clinical studies I have read on glucose metabolism in normal highly insulin sensitive young people (can you say "superhuman"?).
Matt's got some good observations, but is over or mis-interpreting the literature in the realm of endocrinology. I did not notice if he has any medical or scientific credentials, but his views of hormonal action lack nuance, to say the least. He is also avidly mining the "I feel like shite, it must be my thyroid or adrenal glands" meme.
Matt Stone - Paleo Hacks critic
Low-Carb Paleo Eating Ruined Matt Stone's Health? - Paleo Hacks.com
3 | After finding low-carb paleo diet to be perfect for me and my lifestyle I am so dissapointed to hear Matt Stone at 180-degree health refute what I beleive. Stone use to be low-carb paleo and suffered several health problems and talks about his client with the lowest body temperature being a guy after he went LC paleo. I understand people gaining weight after stopping LC paleo bc I beleive they shouldnt be eating foods that aren't LC paleo. But Stone says LC paleo ruins metabolisms. What do you think? low low-carb metabolism thyroid temperature | ||
Atkins Diet & Low Carbohydrate Support
Atkins Diet & Low Carbohydrate Support
Resource website:
Resource website:
"Atkins diet and low carb diet resources for low-carb dieters and all healthy weight-loss seekers: Research, information, support, recipes, success stories, diet tools and tips for all low carbohydrate diet plans."
26.6.11
High LDL on Low-Carb Paleo - causes and cures
Low Carb Paleo, and LDL is Soaring – Help! | Perfect Health Diet
(pre-article to: Answer Day: What Causes High LDL on Low-Carb Paleo? | Perfect Health Diet)
(pre-article to: Answer Day: What Causes High LDL on Low-Carb Paleo? | Perfect Health Diet)
Here’s the puzzle. Someone adopts a low-carb Paleo diet. Very healthy diet, right? But their LDL cholesterol level starts to rise. And rise. And rise.
Larry Eshelman emailed me last December with this problem. His LDL history:
(SI system readers, convert to mmol/l by dividing by 38.67.)
- 103 mg/dl (1990-2002, eating a low fat diet)
- 115 mg/dl (2002-2007, eating a low carb diet)
- 195 mg/dl (2007-2009, after reading Gary Taubes and adding saturated fat)
- 254 mg/dl (Dec 2009, very low-carb Paleo for 5 weeks)
- 295 mg/dl (Jun 2010, very low-carb Paleo for 7 months)
A common problem
This is not a terribly uncommon problem in the Paleo community; it afflicts famous and brilliant bloggers as well as ordinary folks. It’s been discussed by Richard Nikoley in several posts:
Ketogenic Diets - Perfect Health Diet blog
by husband-and-wife team from the Perfect Health Diet blog:
Paul Jaminet, Ph.D. and Shou-Ching Shih Jaminet, Ph.D.
Part 1 - Summary Ketogenic Diets, I: Ways to Make a Diet Ketogenic | Perfect Health Diet
So we have three ways to make the diet ketogenic:
1) Make Wilder’s “ketogenic ratio” high by eating a lot of fat, very few carbs, and not too much protein.
2) Supplement with the ketogenic amino acids lysine and leucine.
3) Supplement with coconut oil or another source of short-chain fats.
If we do (2) or (3), then the diet can be ketogenic even if it has a fair number of carbs.
So now we have an arsenal of ways to generate ketones. We have to look at diseases and diet risks to figure out which way of making the diet ketogenic is optimal.
References
[1] Owen OE et al. Brain metabolism during fasting. J Clin Invest. 1967 Oct;46(10):1589-95. http://pmid.us/6061736.
------------------------------------------
Part 2 - Summary Ketogenic Diets 2: Preventing Muscle and Bone Loss on Ketogenic Diets | Perfect Health Diet
I believe the extreme limits on carb and protein intake in conventional clinical ketogenic diets are responsible for their growth stunting, muscle destroying, fattening effects.
In order to supply sufficient protein and carbs while maintaining ketosis, it is necessary to provide ketogenic short-chain fats and amino acids.
Clinical testing of such supplemented diets has so far produced encouraging results. Providing supplemental amino acids to epileptic children on ketogenic diets improved their health and allowed them to maintain ketosis with higher protein intake. Seizure frequency was reduced even as side effects diminished.
Personally, I wouldn’t attempt a long-term ketogenic diet without the aid of coconut oil (or MCTs), lysine, and the branched chain amino acids.
For the NBIA/PKAN kids, it seems that the amino acid supplements should be some mix of lysine, leucine, isoleucine, and valine, with the isoleucine and valine included solely to reduce leucine toxicity. The optimal amount of isoleucine and valine should be smaller than is found in branched-chain amino acid supplements, since leucine by itself may help prevent iron accumulation and increase ketosis. Also, one rat study [4] indicates that isoleucine alone, excluding valine, might be enough to relieve leucine toxicity. Excluding valine would increase the ketogenicity of the supplement mix.
I think the NBIA/PKAN kids will need to experiment with primarily lysine and leucine, and secondarily isoleucine and BCAA supplements, to see what mix works best for them.
References
[1] Groesbeck DK et al. Long-term use of the ketogenic diet in the treatment of epilepsy. Dev Med Child Neurol. 2006 Dec;48(12):978-81. http://pmid.us/17109786. Hat tip CarbSane.
[2] Ribeiro LC et al. Ketogenic diet-fed rats have increased fat mass and phosphoenolpyruvate carboxykinase activity. Mol Nutr Food Res. 2008 Nov;52(11):1365-71. http://pmid.us/18655006. Hat tip CarbSane.
[3] Evangeliou A et al. Branched chain amino acids as adjunctive therapy to ketogenic diet in epilepsy: pilot study and hypothesis. J Child Neurol. 2009 Oct;24(10):1268-72. http://pmid.us/19687389. Hat tip Nigel Kinbrum.
[4] Tsubuku S et al. Thirteen-week oral toxicity study of branched-chain amino acids in rats. Int J Toxicol. 2004 Mar-Apr;23(2):119-26. http://pmid.us/15204732.
[5] Yudkoff M et al. Brain amino acid requirements and toxicity: the example of leucine. J Nutr. 2005 Jun;135(6 Suppl):1531S-8S. http://pmid.us/15930465.
[6] Mawatari K et al. Prolonged oral treatment with an essential amino acid L-leucine does not affect female reproductive function and embryo-fetal development in rats. Food Chem Toxicol. 2004 Sep;42(9):1505-11. http://pmid.us/15234081.
[7] Tsubuku S et al. Thirteen-week oral toxicity study of L-lysine hydrochloride in rats. Int J Toxicol. 2004 Mar-Apr;23(2):113-8. http://pmid.us/15204731.
Ketogenic Diets | Perfect Health Diet
by husband-and-wife team from the Perfect Health Diet blog:
Paul Jaminet, Ph.D. Paul was an astrophysicist at the Harvard-Smithsonian Center for Astrophysics, became a software entrepreneur during the Internet boom, and now provides strategic advice to entrepreneurial companies while pursuing research in economics (see pauljaminet.com for more information). Paul’s experience overcoming a chronic illness has been key to our views of aging and disease. Paul can be reached by email to pauljaminet@perfecthealthdiet.com.
Shou-Ching Shih Jaminet, Ph.D. Shou-Ching is a molecular biologist and cancer researcher at Beth Israel Deaconess Medical Center and Harvard Medical School, and Director of BIDMC’s Multi-Gene Transcriptional Profiling Core. Shou-Ching was born in Korea to Chinese parents, grew up in Korea, attended college at National Taiwan University in Taipei, and graduate school at University of Newcastle in Australia, before coming to the US to work at Sloan-Kettering Cancer Center, Children’s Hospital Boston, and Beth Israel Deaconess and Harvard Medical School. Her publications may be found by searching Pubmed for “Shih SC.”
Paul Jaminet, Ph.D. and Shou-Ching Shih Jaminet, Ph.D.
Part 1 - Summary Ketogenic Diets, I: Ways to Make a Diet Ketogenic | Perfect Health Diet
So we have three ways to make the diet ketogenic:
1) Make Wilder’s “ketogenic ratio” high by eating a lot of fat, very few carbs, and not too much protein.
2) Supplement with the ketogenic amino acids lysine and leucine.
3) Supplement with coconut oil or another source of short-chain fats.
If we do (2) or (3), then the diet can be ketogenic even if it has a fair number of carbs.
So now we have an arsenal of ways to generate ketones. We have to look at diseases and diet risks to figure out which way of making the diet ketogenic is optimal.
References
[1] Owen OE et al. Brain metabolism during fasting. J Clin Invest. 1967 Oct;46(10):1589-95. http://pmid.us/6061736.------------------------------------------
Part 2 - Summary Ketogenic Diets 2: Preventing Muscle and Bone Loss on Ketogenic Diets | Perfect Health Diet
I believe the extreme limits on carb and protein intake in conventional clinical ketogenic diets are responsible for their growth stunting, muscle destroying, fattening effects.
In order to supply sufficient protein and carbs while maintaining ketosis, it is necessary to provide ketogenic short-chain fats and amino acids.
Clinical testing of such supplemented diets has so far produced encouraging results. Providing supplemental amino acids to epileptic children on ketogenic diets improved their health and allowed them to maintain ketosis with higher protein intake. Seizure frequency was reduced even as side effects diminished.
Personally, I wouldn’t attempt a long-term ketogenic diet without the aid of coconut oil (or MCTs), lysine, and the branched chain amino acids.
For the NBIA/PKAN kids, it seems that the amino acid supplements should be some mix of lysine, leucine, isoleucine, and valine, with the isoleucine and valine included solely to reduce leucine toxicity. The optimal amount of isoleucine and valine should be smaller than is found in branched-chain amino acid supplements, since leucine by itself may help prevent iron accumulation and increase ketosis. Also, one rat study [4] indicates that isoleucine alone, excluding valine, might be enough to relieve leucine toxicity. Excluding valine would increase the ketogenicity of the supplement mix.
I think the NBIA/PKAN kids will need to experiment with primarily lysine and leucine, and secondarily isoleucine and BCAA supplements, to see what mix works best for them.
References
[1] Groesbeck DK et al. Long-term use of the ketogenic diet in the treatment of epilepsy. Dev Med Child Neurol. 2006 Dec;48(12):978-81. http://pmid.us/17109786. Hat tip CarbSane.[2] Ribeiro LC et al. Ketogenic diet-fed rats have increased fat mass and phosphoenolpyruvate carboxykinase activity. Mol Nutr Food Res. 2008 Nov;52(11):1365-71. http://pmid.us/18655006. Hat tip CarbSane.
[3] Evangeliou A et al. Branched chain amino acids as adjunctive therapy to ketogenic diet in epilepsy: pilot study and hypothesis. J Child Neurol. 2009 Oct;24(10):1268-72. http://pmid.us/19687389. Hat tip Nigel Kinbrum.
[4] Tsubuku S et al. Thirteen-week oral toxicity study of branched-chain amino acids in rats. Int J Toxicol. 2004 Mar-Apr;23(2):119-26. http://pmid.us/15204732.
[5] Yudkoff M et al. Brain amino acid requirements and toxicity: the example of leucine. J Nutr. 2005 Jun;135(6 Suppl):1531S-8S. http://pmid.us/15930465.
[6] Mawatari K et al. Prolonged oral treatment with an essential amino acid L-leucine does not affect female reproductive function and embryo-fetal development in rats. Food Chem Toxicol. 2004 Sep;42(9):1505-11. http://pmid.us/15234081.
[7] Tsubuku S et al. Thirteen-week oral toxicity study of L-lysine hydrochloride in rats. Int J Toxicol. 2004 Mar-Apr;23(2):113-8. http://pmid.us/15204731.
Ketogenic Diets | Perfect Health Diet
by husband-and-wife team from the Perfect Health Diet blog:
Paul Jaminet, Ph.D. Paul was an astrophysicist at the Harvard-Smithsonian Center for Astrophysics, became a software entrepreneur during the Internet boom, and now provides strategic advice to entrepreneurial companies while pursuing research in economics (see pauljaminet.com for more information). Paul’s experience overcoming a chronic illness has been key to our views of aging and disease. Paul can be reached by email to pauljaminet@perfecthealthdiet.com.
Shou-Ching Shih Jaminet, Ph.D. Shou-Ching is a molecular biologist and cancer researcher at Beth Israel Deaconess Medical Center and Harvard Medical School, and Director of BIDMC’s Multi-Gene Transcriptional Profiling Core. Shou-Ching was born in Korea to Chinese parents, grew up in Korea, attended college at National Taiwan University in Taipei, and graduate school at University of Newcastle in Australia, before coming to the US to work at Sloan-Kettering Cancer Center, Children’s Hospital Boston, and Beth Israel Deaconess and Harvard Medical School. Her publications may be found by searching Pubmed for “Shih SC.”
25.6.11
Study - low carb improve atherogenic dyslipidemia even without weight loss
Nutrition & Metabolism | Abstract | Low carbohydrate diets improve atherogenic dyslipidemia even in the absence of weight loss
Published: 21 June 2006
A recent report of Krauss et al. (AJCN, 2006) separates the effects of weight loss and carbohydrate restriction. They clearly confirm that carbohydrate restriction leads to an improvement in atherogenic lipid states in the absence of weight loss or in the presence of higher saturated fat. In distinction, low fat diets seem to require weight loss for effective improvement in atherogenic dyslipidemia.
Low carbohydrate diets improve atherogenic dyslipidemia even in the absence of weight loss
Nutrition & Metabolism 2006, 3:24 doi:10.1186/1743-7075-3-24Published: 21 June 2006
Abstract
Because of its effect on insulin, carbohydrate restriction is one of the obvious dietary choices for weight reduction and diabetes. Such interventions generally lead to higher levels of dietary fat than official recommendations and have long been criticized because of potential effects on cardiovascular risk although many literature reports have shown that they are actually protective even in the absence of weight loss.A recent report of Krauss et al. (AJCN, 2006) separates the effects of weight loss and carbohydrate restriction. They clearly confirm that carbohydrate restriction leads to an improvement in atherogenic lipid states in the absence of weight loss or in the presence of higher saturated fat. In distinction, low fat diets seem to require weight loss for effective improvement in atherogenic dyslipidemia.
Study (2004) - more saturated fats, less carb reduces atherosclerosis in postmenopausal women
Dietary fats, carbohydrate, and progression of coronary atherosclerosis in postmenopausal women
Conclusions: In postmenopausal women with relatively low total fat intake, a greater saturated fat intake is associated with less progression of coronary atherosclerosis, whereas carbohydrate intake is associated with a greater progression.
Conclusions: In postmenopausal women with relatively low total fat intake, a greater saturated fat intake is associated with less progression of coronary atherosclerosis, whereas carbohydrate intake is associated with a greater progression.
Dietary fats, carbohydrate, and progression of coronary atherosclerosis in postmenopausal women1,2,3
Dariush Mozaffarian, Eric B Rimm and David M Herrington
1 From the Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, and the Departments of Epidemiology and Nutrition, Harvard School of Public Health, Boston (DM and EBR); the Health Services Research and Development Program, Veterans Affairs Puget Sound Health Care System, Seattle (DM); the Cardiovascular Nutrition Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston (AHL and ATE); and the Section on Cardiology, Department of Internal Medicine, and the Department of Public Health Sciences, Wake Forest University, Winston-Salem, NC (DMH)
23.6.11
Bread equals sugar - Dr. William Davis
Bread equals sugar
by on June 22, 2011 · ( 4 comments ), in Low-carb diets,Wheat
by on June 22, 2011 · ( 4 comments ), in Low-carb diets,Wheat
"Bread, gluten-free or gluten-containing, in terms of carbohydrate content, is equivalent to sugar. Two slices of store-bought whole grain bread, such as the gluten-free bread I discussed in my last post, equals 5- 6 teaspoons of table sugar. Some breads can contain up to twice this quantity, i.e., 10-12 teaspoons equivalent readily-digestible carbohydrate:"
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