....as discussed in Peat vs. Paleo - The Danny Roddy Weblog - Animal-Based Nutrition
Ray Peat on dietary sucrose:
Paleo advocates recommend lower carb diets. Sisson recommends 150 grams (or less) of carbohydrates a day, while others recommend ketogenic levels (50g or less). This is the greatest departure Ray Peat makes from the typical paleo diet.
He states that sugar (sucrose, fructose) is not an issue when polyunsaturated fats are not in the diet.
Showing posts with label glycation. Show all posts
Showing posts with label glycation. Show all posts
25.6.11
PUFA 23 times worse for glycation that carbs - Ray Peat
180 Degree Health: Ray Peat - PUFA
"The name, “glycation,” indicates the addition of sugar groups to proteins, such as occurs in diabetes and old age, but when tested in a controlled experiment, lipid peroxidation of polyunsaturated fatty acids produces the protein damage about 23 times faster than the simple sugars do (Fu, et al., 1996). And the oxidation of fats rather than glucose means that the proteins won't have as much protective carbon dioxide combined with their reactive nitrogen atoms, so the real difference in the organism is likely to be greater than that seen by Fu, et al."
"The name, “glycation,” indicates the addition of sugar groups to proteins, such as occurs in diabetes and old age, but when tested in a controlled experiment, lipid peroxidation of polyunsaturated fatty acids produces the protein damage about 23 times faster than the simple sugars do (Fu, et al., 1996). And the oxidation of fats rather than glucose means that the proteins won't have as much protective carbon dioxide combined with their reactive nitrogen atoms, so the real difference in the organism is likely to be greater than that seen by Fu, et al."
The Daily Lipid: Is Butter High in AGEs?
The Daily Lipid: Is Butter High in AGEs?
Wednesday, October 27, 2010 A butter-loving reader posed the following question to me:
The reader may have seen Dr. William Davis's recent post, "The Anti-AGEing Diet," in which he wrote the following:
Wednesday, October 27, 2010
Is Butter High in AGEs?
Thanks for all the work you do. Any chance you could post something on the AGE content of butter? Does it make a difference if AGEs are endogenously or exogenously produced? Thank in advance.Suffice it to say he liked my answer. I'll repeat it here, with a little more detail.
The reader may have seen Dr. William Davis's recent post, "The Anti-AGEing Diet," in which he wrote the following:
And minimize or avoid butter use, if we are to believe the data that suggest that it contains the highest exogenous AGE content of any known food.Are we to believe this data? I don't.
23.6.11
Type 3 Diabetes - Brain Diabetes?
USPharmacist.com > Type 3 Diabetes: Brain Diabetes?
Type 3 Diabetes: Brain Diabetes?
A relationship between diabetes mellitus (DM) and dementia is undeniable, with numerous studies concluding that DM increases the risk of cognitive decline and dementia, including Alzheimer’s disease (AD).1-5 Not only does DM increase the risk of dementia, it actually increases the rate of dementia development two- to threefold.3
The mechanism of this impairment is not fully understood, but it is hypothesized that hyperglycemia, insulin resistance, oxidative stress, advanced glycation end products, and inflammatory cytokines collectively lead to cognitive dysfunction.5
In fact, diabetes was described as a “special kind of accelerated aging” in 1976 owing to its many associated complications.5
The apparent overlap between DM and dementia has led to the suggestion that AD is not solely a neurologic disorder, but rather a neuroendocrine disorder, with Steen et al coining the term type 3 diabetes to describe this hybrid disease.6
Type 3 Diabetes: Brain Diabetes?
A relationship between diabetes mellitus (DM) and dementia is undeniable, with numerous studies concluding that DM increases the risk of cognitive decline and dementia, including Alzheimer’s disease (AD).1-5 Not only does DM increase the risk of dementia, it actually increases the rate of dementia development two- to threefold.3
The mechanism of this impairment is not fully understood, but it is hypothesized that hyperglycemia, insulin resistance, oxidative stress, advanced glycation end products, and inflammatory cytokines collectively lead to cognitive dysfunction.5
In fact, diabetes was described as a “special kind of accelerated aging” in 1976 owing to its many associated complications.5
The apparent overlap between DM and dementia has led to the suggestion that AD is not solely a neurologic disorder, but rather a neuroendocrine disorder, with Steen et al coining the term type 3 diabetes to describe this hybrid disease.6
12.6.11
Body fueled by fat, not carbs - Dr. Greg Ellis
Phd nutritional biochemist, bodybuilder and author, Dr. Greg Ellis - through 40 years of self-experimentation, and informed by his professional and private scientific research, Ellis says that our bodies can run amazingly well on a fat and protein based diet, and with very little carbohydrates (in his case less than 50 grams per day). he also argues that reduced glycation is a major side-benefit of low carb eating (see: Glycation - causes disease and aging and his recent book on the topic called "The Glycation Factor").
linked here at the Jimmy Moore podcast website is a detailed interview with Ellis - 461: Dr. Greg Ellis Tells Clients To Say ‘Bye Bye, Carbs! and here
the two videos below give very little of the science backing Ellis's contentions, but they made me curious enough to to hear more from him. the first is largely on his background and methodology:
the second is about lean mass production
further resources on Ellis:
linked here at the Jimmy Moore podcast website is a detailed interview with Ellis - 461: Dr. Greg Ellis Tells Clients To Say ‘Bye Bye, Carbs! and here
the two videos below give very little of the science backing Ellis's contentions, but they made me curious enough to to hear more from him. the first is largely on his background and methodology:
the second is about lean mass production
further resources on Ellis:
- bodybuilder website interview: http://www.bodybuilding.com/fun/mahler11.htm
- video of interview: http://www.youtube.com/user/bionicbrown#g/search
- his You Tube video library: http://www.youtube.com/user/Byebyecarbs#g/u
11.6.11
Largely carnivorous - "dont buy into fruit & vegetables"
now 64, he eats largely meat (see also: 50kzone: Totally carnivorous - Augustus Owsley Stanley III). his approach is partly to minimise glycation, a topic he has written a book on called the "Glycation Factor", and see:
- 50kzone: Glycation - Wikipedia
- 50kzone: Glycation - causes disease and aging
- 50kzone: Glycation - heart disease and cancer
his approach is also based on the view that fruit and vegetables are nutritionally unnecessary. he says:
"I want to keep glucose out of my body, and I can only do that by not eating carbohydrates"
"fruits are very high in carbohydrates.....and fructose is a nasty actor too"
"I see no nutritional need for fruit and vegetables....that all started 100 years ago....I don't buy into the need for them"
Ellis says that our bodies can run amazingly well on a fat and protein based diet, and with very little carbohydrates (in his case less than 50 grams per day). further resources on him:
- linked here at the Jimmy Moore podcast website is a detailed interview with Ellis - 461: Dr. Greg Ellis Tells Clients To Say ‘Bye Bye, Carbs! and here
- bodybuilder website interview: http://www.bodybuilding.com/fun/mahler11.htm
- video of interview: http://www.youtube.com/user/bionicbrown#g/search
- his You Tube video library: http://www.youtube.com/user/Byebyecarbs#g/u
Glycation - Wikipedia
Glycation - Wikipedia, the free encyclopedia
Endogenous glycations occur mainly in the bloodstream to a small proportion of the absorbed simple sugars: glucose, fructose, and galactose. It appears that fructose and galactose have approximately ten times the glycation activity of glucose, the primary body fuel.[6]
Glycation - More Sugar = More Wrinkles
first some links to the science supporting the glycation physiology behind this - see:
news media has picked it up - "sugar makes your skin like Crème brûlée"
news media - "Dr Bruce Katz discusses sugar and wrinkles on CBS 2 News, New York" 03/16/10
50kzone: Glycation - Wikipedia
50kzone: Glycation - heart disease and cancer
50kzone: Glycation - causes disease and aging
50kzone: Glycation - drug ad (Nacriderm)
news media has picked it up - "sugar makes your skin like Crème brûlée"
news media - "Dr Bruce Katz discusses sugar and wrinkles on CBS 2 News, New York" 03/16/10
Glycation - drug ad (Nacriderm)
includes a handy precis of glycation process
and see:
and see:
50kzone: Glycation - heart disease and cancer
50kzone: Glycation - causes disease and aging
Glycation - heart disease and cancer
some videos on how glycation works (50kzone: Glycation - Wikipedia)
Definition of Advanced Glycation Endproducts (AGEs) and the consequences of AGE accumulation.
Elevated blood glucose causes Glycation/Advanced Glycation Endproducts (AGEs) through two distinctive pathways: the Maillard reaction/glycation and the oxidative pathway.
Effects of Advanced Glycation Endproducts (AGEs). AGEs play a key role in the development of chronic age related diseases such as diabetes, renal failure, atherosclerosis and Alzheimer's disease. In particular AGEs are involved in the development of the cardiovascular complications of diabetes and renal failure.
Glycation, diabetes, and atherosclerosis
looks like the glycation theory of disease has been around for over a decade - a quick google search produced these hits:
Definition of Advanced Glycation Endproducts (AGEs) and the consequences of AGE accumulation.
Elevated blood glucose causes Glycation/Advanced Glycation Endproducts (AGEs) through two distinctive pathways: the Maillard reaction/glycation and the oxidative pathway.
Effects of Advanced Glycation Endproducts (AGEs). AGEs play a key role in the development of chronic age related diseases such as diabetes, renal failure, atherosclerosis and Alzheimer's disease. In particular AGEs are involved in the development of the cardiovascular complications of diabetes and renal failure.
Glycation, diabetes, and atherosclerosis
looks like the glycation theory of disease has been around for over a decade - a quick google search produced these hits:
glycation cancer - Google Scholar
glycation atherosclerosis - Google Scholar
Protein Glycation, Diabetes, and Aging -- Ulrich and Cerami 56 (1): 1 -- Recent Progress in Hormone Research
Protein glycation, diabetes, and aging. [Recent Prog Horm Res. 2001] - PubMed result
Lipid glycation and protein glycation in diabetes and atherosclerosis. | Mendeley
Advanced glycation end products and vascular infla... [Cardiovasc Res. 2004] - PubMed result
Amazon.com: The Glycation Hypothesis of Atherosclerosis (Medical Intelligence Unit) (9780412114915): Camilo A. L. S. Colaco: Books
Amazon.com: Camilo A. L. S. Colaco: Books, Biography, Blog, Audiobooks, Kindle
Amazon.com: The Glycation Hypothesis of Atherosclerosis (Medical Intelligence Unit) (9783540628545): Camilo A.L.S. Colaco: Books
Advanced Glycation End Product Interventions Reduce Diabetes-Accelerated Atherosclerosis
Advanced Glycosylation End Products Might Promote Atherosclerosis Through Inducing the Immune Maturation of Dendritic Cells -- Ge et al. 25 (10): 2157 -- Arteriosclerosis, Thrombosis, and Vascular Biology
Advanced glycation end products and vascular inflammation: implications for accelerated atherosclerosis in diabetes
Protein Glycation, Diabetes, and Aging -- Ulrich and Cerami 56 (1): 1 -- Recent Progress in Hormone Research
Advanced Glycosylation End Products Might Promote Atherosclerosis Through Inducing the Immune Maturation of Dendritic Cells -- Ge et al. 25 (10): 2157 -- Arteriosclerosis, Thrombosis, and Vascular Biology
Advanced glycation end products and vascular inflammation: implications for accelerated atherosclerosis in diabetes
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