The psych manifestations of mitochon... [J Clin Psychiatry. 2012] - PubMed - NCBI

The psychiatric manifestations of mitochon... [J Clin Psychiatry. 2012] - PubMed - NCBI

J Clin Psychiatry. 2012 Apr;73(4):506-12.


Department of Psychiatry, McMaster University, Hamilton, Ontario, Canada. anglinr@mcmaster.ca



Mitochondrial disorders are caused by gene mutations in mitochondrial or nuclear DNA and affect energy-dependent organs such as the brain. Patients with psychiatric illness, particularly those with medical comorbidities, may have primary mitochondrial disorders. To date, this issue has received little attention in the literature, and mitochondrial disorders are likely underdiagnosed in psychiatric patients.


This article describes a patient who presented with borderline personality disorder and treatment-resistant depression and was ultimately diagnosed with mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) 3271. We also searched the literature for all case reports of patients with mitochondrial disorders who initially present with prominent psychiatric symptoms by using MEDLINE (from 1948-February 2011), Embase (from 1980-February 2011), PsycINFO (from 1806-February 2011), and the search terms mitochondrial disorder, mitochondria, psychiatry, mental disorders, major depression, anxiety, schizophrenia, and psychosis.


Fifty cases of mitochondrial disorders with prominent psychiatric symptomatology were identified.


Information about the psychiatric presentation of the cases was extracted. This information was combined with our case, the most common psychiatric manifestations of mitochondrial disorders were identified, and the important diagnostic and treatment implications for patients with psychiatric illness were reviewed.


The most common psychiatric presentations in the cases of mitochondrial disorders included mood disorder, cognitive deterioration, psychosis, and anxiety. The most common diagnosis (52% of cases) was a MELAS mutation. Other genetic mitochondrial diagnoses included polymerase gamma mutations, Kearns-Sayre syndrome, mitochondrial DNA deletions, point mutations, twinkle mutations, and novel mutations.


Patients with mitochondrial disorders can present with primary psychiatric symptomatology, including mood disorder, cognitive impairment, psychosis, and anxiety. Psychiatrists need to be aware of the clinical features that are indicative of a mitochondrial disorder, investigate patients with suggestive presentations, and be knowledgeable about the treatment implications of the diagnosis.
© Copyright 2012 Physicians Postgraduate Press, Inc.

[PubMed - indexed for MEDLINE]

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Cholesterol and Fats in Blood - Department of Biochemistry and Biophysics UCSF

Uploaded by on Sep 17, 2009
Tracy Fulton, Professor, in the Department of Biochemistry and Biophysics UCSF explores cholesterol and fat in blood. Series: UCSF Mini Medical School for the Public [9/2009] [Health and Medicine] [Show ID: 16716]

All Comments (25)

small ant
  • i bet she is in favor of us all eating canola fried foods. nothing goes better than heart disease than a little lipitor induced heart tissue damage combined with some rape seed oil toxins. when this bitch dies i hope she burns in hell. her entire crowd know they are soft killing us because we are two stupid to figure it all out. well fuck you i figured it out you sorry bitch.
  • the fiber while an irritant to the gut of wheat damaged human does not bother humans that do not eat irritating foods such as grains, legumes or milk. its just no fiber study has been done on humans that eat low carb diets. however if fiber is causeing you gastic issue you need to dump it from your personal diet. i also have taken my own responsibility for my health.
  • my trigycerides are 48. un godly low. i eat all the fat i can tolerate. i actually keep a spoon and a tub of coconut oil beside my computer so i wont froget to take my daily dose. it has in it a fatty acid that kills bacteria,fungi,virus and i have been told some parasites. yet it is a food and not a medicine.
  • What about the suppressed truth by many "real scientists" who don't have an agenda to fill like Vilhjalmur Stefansson ... have a read here... dub dub dub drbass dot com/stefansson1 dot html
  • So you got that too! I'm right there with you on that!
  • I'm 47 and haven't seen a doctor in many years... EVERYONE I KNOW , especially my age and older who have a history of going to the doc and taking the drugs ALL have worse problems than me and at 47 I haven't done the best I could but I'm paving my own way to grow old healthy and strong ...I cut out sugar and went primal,,,then I removed all fiber and now eat my eggs and meats raw and I never felt better! Look up "Fiber Menace" and "Nora Gedgaudas" and "WAPF" and "Aajonus Vonderplanitz" Greatness
  • the carriers of lipids have receptors on targets and DAMAGED TISSUE. the deposition on arterial walls is by design not by accident. diet has no effect. this was proven in 1985 by a couple of Nobel prize winners. do not buy into the lipid disease hypothesis
  • what are you trying to cure? a blood profile or an actual disease process?
  • she takes money from the lipitor mafia, they are all the same. oh they understant fructose none give a damn though they are out to get rich by spreading lies.
  • mmkay?
  • she lost me at "the types of fatty acids you eat influence your lipid profiles more than eating actual cholesterol"... not one comment on how fructose is the actual culprit for high triglycerides. She glossed over diet completely and jumped straight onto the old "drugs will save us" bandwagon. Too bad.
  • snarky lady, I think she's on lipitor cause she doesn't act right. Screw drugs, I'll continue with self treatment with nutrients.
  • She is more like a high school science teacher.