| Many aggressive cancers depend on anaerobic glycolysis for ATP production, as has been known since first described by Otto Warburg in the 1920’s. The remarkable success of modern PET scanning in the detection, staging and prognosis of many cancers using F-18 Fluorodeoxyglucose (FDG) reflects this dependence. Very low carbohydrate ketogenic (VLCK) diets have inhibited cancer growth in animal studies and in a human case study. Ketone bodies in culture media have inhibited cancer growth in cell culture studies [1], [5], [6]. While the mechanism of cancer inhibition is unlikely to be simple glucose deprivation, several plausible mechanisms have been proposed. VLCK diets cause tonic reductions in hormones that are supportive of tumor growth including insulin, IGF7, IL6 and other inflammatory cytokines. Other metabolic effects include apoptosis due to increased plasma fatty acids, and inhibition of fatty acid synthase, a target of chemotherapeutic agents. While we actively explore cellular and metabolic effects of ketone bodies themselves in our own laboratories, we are also recruiting patients in a nutritional Clinical Trial of carbohydrate restriction in collaboration between the Albert Einstein College of Medicine and Downstate Medical Center. The two principle aims are to: 1) Determine safety and feasibility of a 28 day VLCK diet in 12 subjects with FDG avid cancers. 2) Monitor change in PET FDG uptake between the beginning and end of the trial as a surrogate marker for efficacy (as has been done in lymphoma, lung cancer, breast cancer and other malignancies). Five patients with metastatic cancer have completed four weeks of a VLCK diet without adverse effects. We are looking to recruit another 7 patients. Please take a look at our website for more information. |
Showing posts with label carb - cancer. Show all posts
Showing posts with label carb - cancer. Show all posts
1.7.11
Diet & Cancer - Metabolism Society
23.6.11
low carb & paleo related studies - 78 reference links
library of low carb and paleo related study links - 78 of them:
American Journal of Clinical Nutrition:
• Carbohydrate nutrition and inflammatory disease mortality in older adults
• Carbohydrate quantity and quality and risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition–Netherlands (EPIC-NL) study
• Dietary intake of saturated fatty acids and mortality from cardiovascular disease in Japanese: the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC) Study
• Effect of a low glycemic index compared with a conventional healthy diet on polycystic ovary syndrome
• Effects of glycemic load on metabolic risk markers in subjects at increased risk of developing metabolic syndrome
• Gluconeogenesis and energy expenditure after a high-protein, carbohydrate-free diet
• High protein intake reduces intrahepatocellular lipid deposition in humans
• Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease
• Saturated fat, carbohydrate, and cardiovascular disease
American Journal of Clinical Nutrition:
• Carbohydrate nutrition and inflammatory disease mortality in older adults
• Carbohydrate quantity and quality and risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition–Netherlands (EPIC-NL) study
• Dietary intake of saturated fatty acids and mortality from cardiovascular disease in Japanese: the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC) Study
• Effect of a low glycemic index compared with a conventional healthy diet on polycystic ovary syndrome
• Effects of glycemic load on metabolic risk markers in subjects at increased risk of developing metabolic syndrome
• Gluconeogenesis and energy expenditure after a high-protein, carbohydrate-free diet
• High protein intake reduces intrahepatocellular lipid deposition in humans
• Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease
• Saturated fat, carbohydrate, and cardiovascular disease
Ketogenic Diets and Cancer Cure - 11 references
Reference links relating to ketogenic diets and curing cancer:
1. Available Carbohydrates, Glycemic Load, and Pancreatic Cancer: Is There a Link?
2. The Effects of Varying Dietary Carbohydrate and Fat Content on Survival in a Murine LNCaP Prostate Cancer Xenograft Model
3. Ketogenic Diet to Treat Cancer
4. Carbohydrates are addictive
5. Ketogenic Diet: New Cancer Treatment or Old Ignored Anti-Cancer Strategy?
6. Repeated measures of serum glucose and insulin in relation to postmenopausal breast cancer
7. The ERGO trial: A pilot study of a ketogenic diet in patients with recurrent glioblastoma
8. The calorically restricted ketogenic diet, an effective alternative therapy for malignant brain cancer
9. Cancer & Ketosis
10. Can Ketogenic Diet Cure Cancer?
11. Can a High Fat Diet Beat Cancer?
1. Available Carbohydrates, Glycemic Load, and Pancreatic Cancer: Is There a Link?
2. The Effects of Varying Dietary Carbohydrate and Fat Content on Survival in a Murine LNCaP Prostate Cancer Xenograft Model
3. Ketogenic Diet to Treat Cancer
4. Carbohydrates are addictive
5. Ketogenic Diet: New Cancer Treatment or Old Ignored Anti-Cancer Strategy?
6. Repeated measures of serum glucose and insulin in relation to postmenopausal breast cancer
7. The ERGO trial: A pilot study of a ketogenic diet in patients with recurrent glioblastoma
8. The calorically restricted ketogenic diet, an effective alternative therapy for malignant brain cancer
9. Cancer & Ketosis
10. Can Ketogenic Diet Cure Cancer?
11. Can a High Fat Diet Beat Cancer?
Carbohydrates And Cancer: The Prospect
Carbohydrates And Cancer: The Prospect | Carbohydrates Can Kill
Robert Su, Pharm.B., M.D.
Full article:
Robert Su, Pharm.B., M.D.
Full article:
Carbohydrates And Cancer - Studies on the link
Carbohydrates And Cancer: The Link | Carbohydrates Can Kill
Robert Su, Pharm. B., M.D.
Extracts:
Studying the impact of foods on health has been very difficult. Gathering the dietary information from individuals based on their recollection is not totally reliable. The design of a study, such as the selection of participants and the criteria for the control group and test group(s), may significantly affect its result(s) and conclusion.
Despite that studies have claimed various factors, including fat, infection, inflammation, and others, are carcinogenic, some recent studies have linked carbohydrates to the development of different cancers. Some of the linkages might not be strongly positive. However, the vague linkages are worth taking another look at the causal role of carbohydrates in developing cancers. [4]
Robert Su, Pharm. B., M.D.
Extracts:
Studying the impact of foods on health has been very difficult. Gathering the dietary information from individuals based on their recollection is not totally reliable. The design of a study, such as the selection of participants and the criteria for the control group and test group(s), may significantly affect its result(s) and conclusion.
Despite that studies have claimed various factors, including fat, infection, inflammation, and others, are carcinogenic, some recent studies have linked carbohydrates to the development of different cancers. Some of the linkages might not be strongly positive. However, the vague linkages are worth taking another look at the causal role of carbohydrates in developing cancers. [4]
Carbohydrates And Cancer - the connection
Carbohydrates And Cancer: The Fact | Carbohydrates Can Kill
Robert Su, Pharm.B., M.D.
"Concurrently, we have witnessed a growing number of cancers. Until recently, fats had been thought responsible for the development of cancers. [13] Now, more evidence shows a link between hyperglycemia and some, if not all, cancers. [14] With better design of research projects, we can expect that this link will become apparent.
Most importantly, we must recognize and bear in mind that excessive carbohydrate intake causes hyperglycemia, diabetes mellitus, and overweight/obesity. [15]
What we have known about glucose and some, if not all, cancers so far is:
Robert Su, Pharm.B., M.D.
"Concurrently, we have witnessed a growing number of cancers. Until recently, fats had been thought responsible for the development of cancers. [13] Now, more evidence shows a link between hyperglycemia and some, if not all, cancers. [14] With better design of research projects, we can expect that this link will become apparent.
Most importantly, we must recognize and bear in mind that excessive carbohydrate intake causes hyperglycemia, diabetes mellitus, and overweight/obesity. [15]
What we have known about glucose and some, if not all, cancers so far is:
Carbohydrates and Colon Cancer
Carbohydrates and Colon Cancer | Carbohydrates Can Kill
Robert Su, Pharm.B., M.D.
"Despite several studies denied the connection between the incidence of colorectal cancer and glycemic index, glycemic load, and carbohydrates consumption, [7, 8] the data from nearly 1.3 million individuals used in Jee’s study can hardly be ignored.
Robert Su, Pharm.B., M.D.
"Despite several studies denied the connection between the incidence of colorectal cancer and glycemic index, glycemic load, and carbohydrates consumption, [7, 8] the data from nearly 1.3 million individuals used in Jee’s study can hardly be ignored.
In addition, more recent studies supported the link between the risk of colorectal cancer and the consumption of carbohydrates. [9, 10] Gnagnarella P et al summarized, “This comprehensive meta-analysis of GI and GL and cancer risk suggested an overall direct association with colorectal and endometrial cancer.” [11] Barclay AW et al concluded, “The findings support the hypothesis that higher postprandial glycemia is a universal mechanism for disease progression.” [12]
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