Insulin-like growth factor 1

Insulin-like growth factor 1

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Insulin-like growth factor 1 (IGF-1), also called somatomedin C, is a protein that in humans is encoded by the IGF1 gene.[1][2] IGF-1 has also been referred to as a "sulfation factor"[3] and its effects were termed "nonsuppressible insulin-like activity" (NSILA) in the 1970s.

IGF-1 is a hormone similar in molecular structure to insulin. It plays an important role in childhood growth and continues to have anabolic effects in adults. A synthetic analog of IGF-1, mecasermin is used for the treatment of growth failure.[4]

IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges. IGF-1 has a molecular weight of 7649 daltons.


Insulin-like growth factor 1 (somatomedin C)

PDB rendering based on 1bqt.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols IGF1; IGF-I; IGF1A; IGFI
External IDs OMIM147440 MGI96432 HomoloGene515 GeneCards: IGF1 Gene
RNA expression pattern
PBB GE IGF1 209541 at.png
PBB GE IGF1 209540 at.png
PBB GE IGF1 209542 x at.png
More reference expression data
Species Human Mouse
Entrez 3479 16000
Ensembl ENSG00000017427 ENSMUSG00000020053
UniProt P05019 P05017
RefSeq (mRNA) NM_000618.3 NM_001111274.1
RefSeq (protein) NP_000609.1 NP_001104744.1
Location (UCSC) Chr 12:
102.79 – 102.87 Mb
Chr 10:
87.32 – 87.4 Mb

PubMed search [1] [2]