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Celiac Disease - National Digestive Diseases Information Clearinghouse

Celiac Disease - National Digestive Diseases Information Clearinghouse -

Celiac Disease
What is celiac disease?

Celiac disease is both a disease of malabsorption—meaning nutrients are not absorbed properly—and an abnormal immune reaction to gluten... that damages the small intestine.

People who have celiac disease cannot tolerate gluten, a protein in wheat, rye, and barley.

When people with celiac disease eat foods or use products containing gluten, their immune system responds by damaging or destroying villi—the tiny, fingerlike protrusions lining the small intestine. Villi normally allow nutrients from food to be absorbed through the walls of the small intestine into the bloodstream. Without healthy villi, a person becomes malnourished, no matter how much food one eats.
Drawing of a section of the small intestine with detail of villi. The small intestine and villi are labeled.
Villi on the lining of the small intestine help absorb nutrients.