EXTRACTS - Why cells go bad: a new appreciation and understanding of ATP opens up an untapped avenue for fighting diabetes, cancer, aging, etc. - Andrew Kim Blog
It’s due to this line of reasoning that carbohydrates, and especially sugar and fructose, have fallen by the wayside of late, driven by an irrational fear, bordering on obsessiveness, that’s evolved to where sugar is now conceived of as a toxic poison and blamed for causing diabetes, cancer, obesity, gout, etc. (Thank you Dr. Lustig).
It’s important to point out that sugar is used by virtually every cell in the body to generate energy, or ATP. The brain is especially reliant on glucose for optimal functioning: The brain represents only 2 percent of the body’s total weight yet accounts for 15 percent of the body’s total energy expenditure. 1 Indeed, the brain is a voracious sugar guzzler, and sugar, not ketone bodies, is its preferred fuel source, despite popular discourse to the contrary. Insulin and sugar make us smarter 2 so it stands to reason that ketosis has the opposite effect.
If we were to accept the theory of Warburg and others, that a high efficiency of energy generation determines structure, and that structure in turn, namely of the protein complexes of the respiratory chain, determines how we produce energy—via respiration or fermentation—then, glucose, oxygen, and insulin are the fundamental factors that make up the provision of support against cancer formation; high fat diets (and diabetes) would tend to promote it.
Warburg also noted that the availability of blood sugar (in the presence of insulin) had no effect on the growth or survival of tumors, and so restricting sugar in hopes of staving off cancer is as fruitless an endeavor as restricting cholesterol to prevent cardiovascular disease, or restricting calcium to slow the progression of pathological calcification processes in the arteries, and so on.
In reality, sugar, in the form of fruit promotes respiration and, in part through insulin, is protective against diabetes and cancer. Fruit supplies other nutrients that support respiration, including magnesium, potassium, vitamin B1, and vitamin c, which also promotes the absorption of iron in the intestines. Carbohydrates, in general, suppress the liberation of fatty acids and amino acids, and inhibit the production of ketone bodies and glucose in the liver, all of which prevent the oxidative metabolism of glucose via the PDH complex, and interfere with the delicately poised state of the mitochondrial respiratory chain. Fructose, which is present in fruit but not starches, stimulates the synthesis of cholesterol more than any other single nutrient, and this means that ubiquinone would almost assuredly be produced in the amounts needed by cells.
Insulin, glucose, and oxygen the fundamental factors that make up our resistance to stress and illnesses. There are issues inherent in the excessive oxidation of fatty acids in preference to glucose, which is beyond the scope of this post. (Though Danny Roddy laid out the differences between the two here.) Briefly, glucose oxidation, more than fatty acid oxidation, supports a highly energized cellular state, per Dr. Gilbert Ling’s vision of cell physiology, and this in turn establishes a firmer connection between energy generation and structure, allowing cells—and by extension people—to exist at the highest possible state of functioning, refinement, complexity.